A Mutated Vitamin D Receptor in Hereditary Vitamin D-Resistant Rickets Prevents Induction of Bronchial Hyperreactivity and Inflammation

摘要

Context:Previous studies have reported an association between vitamin D deficiency and asthma. Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) patients provide a natural model to assess the role of the vitamin D receptor (VDR) in regulating human lung immune responses and airway hyperreactivity.