Modifications in the Papillary Thyroid Cancer Gene Profile Over the Last 15 Years

摘要

Background:Evidence for an increased prevalence of BRAF ~(V600E) mutations has been documented in recent decades. The aim of this study was to evaluate the prevalence of both RET / PTC rearrangements and BRAF ~(V600E) mutations in an Italian cohort of papillary thyroid carcinoma (PTC) patients followed at the Endocrine Units of Pisa, Milano, and Perugia from 1996–2010.