Malaria parasitemia and its association with lipid and hematological parameters among malaria-infected patients attending at Metema Hospital, Northwest Ethiopia

摘要

Background: Malaria is a major public health problem in Ethiopia with wide-ranging hematological and biochemical alterations. Therefore, the aim of this study was to assess malaria parasitemia and its association with lipid and hematological parameters. Methods: A comparative cross-sectional study was conducted from April 1 to June 30, 2014. Of 200 study participants, 100 were confirmed malaria patients and 100 healthy controls. Study participants were included based on systematic random sampling techniques. Seven milliliters of blood samples were collected for investigation of hematological and lipid parameters. Data were entered and analyzed using SPSS-20 statistical software. Independent t -test and one-way analysis of variance were run to compare mean differences. A P 3/μL), neutrophil (63.1%±8.7% vs 56.0%±12.7%), hemoglobin (11.9±2.0 vs 14.5±3.0 gm/dL), hematocrit (36.2%±7.8% vs 42.4%±8.3%), platelet count ([175.3±136 vs 193.4±81.9]×103/μL), high-density lipoprotein (19.6±13.7 vs 35.5±12.3 mg/dL), low-density lipoprotein (34.7±23.5 vs 64.5±29.3?mg/dL), triglyceride (118.0±61.3 vs 101.7±36.8 mg/dL), and total cholesterol (88.0±36.3 vs 148.7±39.1 mg/dL) for cases and controls, respectively ( P 3/uL) among low, moderate, and high parasitemia, respectively. Conclusion: This study revealed that routinely used laboratory tests such as lipid and hematological parameters could be good and reliable adjunct in the early diagnosis of malaria-infected patients with mild-to-severe parasitemia in malaria endemic areas.