Interferon ALFA (INF-α) use during pregnancy: A case report in chronic myeloid leukemia and a review literature

摘要

A patient with Philadelphia chromosome positive chronic myeloid leukemia (CML) being treated with INF-a conceived during treatment which continued for the whole course of her pregnancy. A female infant was born at 40th week of gestation and was found to have a platelet count of 56 x 109/L which returned to normal after two weeks. A literature review of similar cases showed no abnormalities in the infants of mothers receiving INF-a during pregnancy. The safety of INF-a during pregnancy requires further study before its routine use during pregnancy can be recommended.