Need for speed: An optimized gridding approach for spatially explicit disease simulations

摘要

Author summary Numerical models for simulating the outbreak of infectious disease are powerful tools that can be used to inform policy decisions by simulating outbreaks and control actions. However, they rely on considerable computational power to explore all outcomes and scenarios of interest. Focusing on model types commonly used for livestock diseases, we here introduce novel algorithms for efficient computation, alongside techniques to optimize them based on simplifying assumptions. Through simulations of FMD outbreak in the US, the UK and Sweden, as well as in computer generated landscapes, we test how these methods perform under realistic conditions. We find that our optimization techniques works well, and when the introduced algorithms are implemented with these optimizations, computation time can be reduced by more than two orders of magnitude compared to pairwise calculations. We propose that the considered algorithms—which are straight forward to implement—will be useful for simulation of a wide range of diseases, and will promote the use of simulation models for policy recommendation.