Effects of a triplex mixture of Peganum harmala, Rhus coriaria , and Urtica dioica aqueous extracts on metabolic and histological parameters in diabetic rats

摘要

Context: Several therapeutic effects such as antioxidant and blood glucose-lowering activities have been reported for Peganum harmala L (Zygophyllaceae) (PH) seeds, Rhus coriaria L (Anacardiaceae) (RC) fruits, and Urtica dioica L (Urticaceae) (UD) leaves.Objective: This study investigates the effects of a triplex mixture (1:1:1) of these medicinal plants on metabolic and histological parameters in diabetic rats.Materials and methods: Aqueous extracts of PH, RC and UD were administered as either monotherapy or in combination at a final dose of 200?mg/kg to alloxan-induced diabetic rats by daily gavage. Biochemical parameters including blood glucose, liver function-related enzymes, lipid profile, and creatinine were estimated by spectrophotometric methods. Tissues from the liver and kidney stained with hematoxylin/eosin were histologically examined. The results obtained from the exposure groups were compared to either healthy or diabetic control groups.Results: Compared with the diabetic control rats, all aqueous extracts (ED₅₀?=?11.5?±?2.57?mg/ml) led to significant decreases in the levels of ALP (1.39–2.23-fold, p?p?p?p?Conclusion: This study showed that PH, RC, and UD extracts, especially their combination, had significant antidiabetic, hypolipidemic, and liver and renal damage recovering effects.