Pneumonia and empyema caused by Methylobacterium in a patient with X-linked chronic granulomatous disease

摘要

Chronic granulomatous disease (CGD) is a rare primary immunodeficiencydisease with an incidence of 1/250,000.1This disease is caused by genetic defects in the nicotinamideadenine dinucleotide phosphate oxidase complex,which includes gp91phox, p22phox, p40phox, p47phox, andp67phox; mutations in these genes can lead to failure in theproduction of microbicidal superoxide anions and theassociated phagocyte-derived reactive oxygen species.2These genetic defects can further result in the developmentof recurrent life-threatening fungal and/or bacterialinfections, granuloma formation, and inflammatory processes.