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Change and variability in drug treatment coverage among people who inject drugs in 90 large metropolitan areas in the USA, 1993–2007

机译:1993年至2007年,美国90个大都市区的注射毒品者中药物治疗覆盖率的变化和变异性

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Our previous research has found low and stable mean drug treatment coverage among people who inject drugs (PWID) across 90 large US metropolitan statistical areas (MSAs) during 1993–2002. This manuscript updates previous estimates of change in drug treatment coverage for PWID in 90 MSAs during 1993–2007. Our drug treatment sample for calculating treatment coverage includes clients enrolled in residential or ambulatory inpatient/outpatient care, detoxification services, and methadone maintenance therapy at publicly- and privately-funded substance abuse agencies receiving public funds. Coverage was measured as the number of PWID in drug treatment, calculated by using data from the Substance Abuse and Mental Health Service Administration, divided by numbers of PWID in each MSA. We modeled change in drug treatment coverage rates using a negative binomial mixed-effects model. Fixed-effects included an intercept and a main effect for time. Incidence rate ratios (IRR) were calculated for both average change from 1993 to 2007 and MSA-specific estimates of change in coverage rates. On average over all MSAs, coverage was low in 1993 (6.1%) and showed no improvement from 1993 to 2007 (IRR?=?0.99; 95% CI, 0.86, 1.2). There was modest variability across MSAs in coverage in 1993 (log incidence rate SD?=?0.36) as well as in coverage change from 1993 to 2007 (log IRR SD?=?0.32). In addition, results indicate significant variability among MSAs in coverage. Inadequate treatment coverage for PWID may produce a high cost to society in terms of the spread of overdose mortality and injection-related infectious diseases. A greater investment in treatment will likely be needed to have a substantial and more consistent impact on injection drug use-related harms. Future research should examine MSA-level predictors associated with variability in drug treatment coverage.
机译:我们以前的研究发现,在1993年至2002年期间,美国90个大都市统计区(MSA)的注射毒品者(PWID)的平均药物治疗覆盖率较低且稳定。该手稿更新了先前对1993年至2007年间90个MSA中PWID药物治疗覆盖率变化的估计。我们用于计算治疗覆盖率的药物治疗样本包括接受公共资金的公共和私人资助的药物滥用机构的住院或门诊住院/门诊,排毒服务和美沙酮维持治疗的客户。覆盖率以药物治疗中PWID的数量来衡量,方法是使用药物滥用和精神卫生服务管理局的数据除以每个MSA中的PWID数量。我们使用负二项式混合效应模型来模拟药物治疗覆盖率的变化。固定效果包括截距和时间的主要效果。计算1993年至2007年的平均变化率和MSA特定的覆盖率变化估计值的发病率比率(IRR)。平均而言,所有MSA的覆盖率在1993年都很低(6.1%),并且从1993年到2007年没有改善(IRR?=?0.99; 95%CI,0.86,1.2)。 1993年的覆盖范围(对数发生率SD≥0.36)以及1993年至2007年的覆盖范围变化(对数IRR SD≤0.32)之间的MSA差异均较小。此外,结果表明MSA覆盖范围之间存在很大差异。就过量死亡和注射相关感染性疾病的传播而言,PWID治疗覆盖率不足可能给社会带来高昂的代价。可能需要加大治疗投入,才能对与注射毒品相关的危害产生实质性且更一致的影响。未来的研究应检查与药物治疗范围变异性相关的MSA级预测因子。

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