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Semiparametric transformation models with length-biased and right-censored data under the case-cohort design

机译:案例队列设计下具有长度偏向和右删失数据的半参数转换模型

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Case-cohort designs provide a cost effective way in large cohort studies. Semiparametric transformation models, which include the proportional hazards model and the proportional odds model as special cases, are considered here for length-biased right-censored data under case-cohort design. Weighted estimating equations, which can be used even when the censoring variables are dependent of the covariates, are proposed for simultaneous estimation of the regression parameters and the transformation function. The resulting regression estimators are shown to be asymptotically normal with a closed form of variance-covariance matrix and can be estimated by the plug-in method. Simulation studies show that the proposed approach performs well for practical use. An application to the Oscar data is also given to illustrate the methodology.
机译:案例队列设计为大型队列研究提供了一种经济高效的方法。在案例队列设计下,针对长度偏向的右删失数据,考虑了半参数转换模型,其中包括比例风险模型和比例赔率模型作为特例。提出了即使在检查变量依赖于协变量时也可以使用的加权估计方程,用于同时估计回归参数和变换函数。结果表明,回归估计量是渐近正态的,具有封闭形式的方差-协方差矩阵,可以通过插件方法进行估计。仿真研究表明,所提出的方法在实际应用中表现良好。还提供了对Oscar数据的应用以说明该方法。

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