Objectives: The aim of this work was to illustrate the relation between the epigenetics and rheumatic diseases and the novel epigenetic therapies. Data Sources: Data sources were obtained from the Medline databases (Pub Med, Science Direct, and Medscape). Article Selection: This article studied the epigenetics role in rheumatic diseases and the recent epigenetic therapies. Data Synthesis: Short reviews were performed in the pathophysiology of the rheumatic disorders in association with epigenetic modifications. Conclusion: Despite the epigenetic mechanisms are involved in many rheumatic diseases, yet enhanced understanding of the reversible epigenetic alterations that change gene expression could help in paving the way for prospective treatments of several rheumatic diseases.
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