Immune mediated thrombophilia: Role of innate immunity

摘要

Objectives: The aim of this work is to illustrate immune system, hemostasis, thrombosis, inflammation, relations between (hemostasis and immune system, inflammation and immune system) and finally relation between immune system especially the innate immunity and thrombosis. Data Sources: Medline database s (PubMed, Medscape and Science direct). Article Selection: This article studied the roleof the immune system especially the innate immunity in hypercoagulable state. Data Synthesis: Short reviews were made on pathophysiology of hybercoagulability associated with innate immune system dysregulation. Conclusion : Despite the innate immunity plays an important role in our immune system, yet its dysregulation is accompanied by different blood diseases, and further elucidation of the underlying defects in its pathways is awaited to develop pathogenesis (hypercoagulability).