Objective: Evaluate the efficacy and tolerability of topical KOH solution in the treatment of plane wart . Background: Plane wart is a common dermatological disease that is caused by human papilloma virus; although the rate of spontaneous recovery is high, it usually takes a long time to occur. Many modalities of treatments have been used but none of them proved to be uniformly effective. Potassium hydroxide (KOH) solution is a well-known keratolytic agent with many dermatological uses. Materials and Methods: A total of 100 patients with plane warts, were enrolled in this opened therapeutic trial study. Patients were divided into two age and sex cross-matched equal groups? patients in group (A) were treated with topical 10% KOH solution once at night, while patients in group (B) were treated with topical 15% KOH solution once nightly. Only 42 patients from group (A) and 40 patients from group (B) completed the study, while the remainders were defaulted for unknown reasons. The patients were evaluated at second and fourth week to assess the cure rates and side effects, those patients who showed complete cure were followed up for 3 months to detect any recurrence. Results: At the end of second week, 66.7% of group (A) patients showed complete disappearance of their warts, vs 75% of group (B) patients. At the end of fourth week, 81% of group (A) patients showed complete response in comparison with 87.5% of group (B) patients. The side effects for the treating solution in both concentrations include itching, burning sensation, erythema, and temporary dyspigmentations, that were reported in 73.8% of group (A) patients in comparison with 90.5% of group (B) patients. Recurrence rate was reported in 11.9% of group (A) patients vs 5% of group (B) patients during the three months period of follow up. Conclusions: Topical KOH solution is proved to be an effective and safe treatment of plane warts in both concentrations (10% and 15%) with no important side effects.
展开▼
