Monoclonal gammopathy of renal significance

摘要

Background: monoclonal gammopathy is an immune disease with immune-globulin or part of it is produced by clonal propagation of cells in B-lymphocytes. Its role in renal disease is recently studied. However, the field had many gaps in the understanding of the disease. Aim of the work: to study the role of monoclonal gammopathy of renal importance. Methods: an internet based search during the last 20 years with a keyword search of monoclonal gammopathy in the title of papers was done. Studies with sufficient data about the topic were thoroughly reviewed and the important results were included in the present work. Results: monoclonal immunoglobulins were found to have the ability to lead to different renal disorders resulting from the direct renal deposition of the monoclonal imuunoglobulin (MIg), and rarely from an indirect mechanism via dysregulation of the alternative pathway of complement. Conclusion: The monoclonal gammopathy-associated renal diseases are distinct in their pathogenesis, kidney biopsy findings, clinical presentation, progression, prognosis, and treatment. A thorough and complete evaluation of the MIg-associated renal disease needs to be performed to appropriately.