Distribution of CYP2B6 516G/T pharmacogenetically important polymorphism in the Ukrainian population

摘要

The CYP2B6 is one of the members of the cytochrome P450 superfamily. This enzyme metabolizes a number of currently prescribed drugs and different compounds. In light of clinical significance of the CYP2B6?6 variant of the CYP2B6 gene, the aim of this study was to investigate the distribution of one of the gene polymorphisms, namely, the 516G/T in the Ukrainian population.The study cohort consisted of 102 healthy Ukrainian adults (48 males, 54 females). Genotyping of the CYP2B6 (rs3745274) polymorphism in the study subjects was carried out using a polymerase chain reaction.The following distribution of 516G/T CYP2B6 genotypes in the Ukrainian cohort was identified: GG – in 56%, GT – in 37% and TT – in 7%. The 516G/T allele frequency of the CYP2B6 gene in population was pG = 0.75 and qT = 0.25, respectively. The population-based sequences were analyzed by the Hardy-Weinberg method.The genetic polymorphism revealed in the Ukrainian population suggests the 516G/T polymorphism of the CYP2B6 genetic testing when prescribing the drugs that are substrates of this gene.