Current Trend for the Accurate Determination of Active Pharmaceutical Ingredients in Blood, Serum and Urine Samples by Mcnts@MIP Using Chromatographic Techniques

摘要

Magnetic carbon nanotubes with magnetic imprinted polymer (MCNTs@MIP) extraction techniques are great current interest for the determination of active pharmaceutical ingredients. Magnetic carbon nanotubes (MCNTs) can be manipulated by magnetic fields, so that when functionalized, they can be used for the purification and separation of biomolecules and even whole cells. The aim of this study was to understand the interaction between carbon nanotubes (CNTs) and active pharmaceutical ingredients and evaluate the drug-loading ability of CNTs. Molecularly imprinted polymers (MIPs) are artificially synthesized polymeric materials, each of which contains a large number of cavities that are complementary in terms of shape, size, and functional groups present to a specific target molecule. Therefore, MIPs show the ability to recognize specific molecules, and high binding affinities for these target molecules. In recent years, MIPs have been widely used in various fields, such as separations, sensors, and catalysis. AbbreviationsMIPs, molecularly imprinted polymers; MCNTs@MIP, magnetic carbon nanotubes with magnetic imprinted polymer.