SILICASUPPORTED COPPER(II) OXIDE FOR THE SYNTHESIS OF CURCUMIN DERIVATIVES CONTAINING PYRAZOLE AND ISOXAZOLE SCAFFOLDS

摘要

Preparation of CuO/SiO_2catalyst has been done via sol-gel method using copper nitrate solution and TEOS as precursors. Several instruments such as FT-IR, SEM, EDAX, XRD and particle sizer were employed to characterize the obtained material. Then, CuO/SiO_2 catalyst was successfullyusedin the synthesis of three curcumin derivatives, 4,4'-((1E,1'E)-(1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 1), 4,4'-((1E,1'E)-(1- phenyl-1H-pyrazole-3,5-diyl)bis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 2) and 4,4'-((1E,1'E)- (isoxazole-3,5-diylbis(ethene-2,1-diyl))bis(2-methoxyphenol) (Compound 3) with good yields.