Teedia lucida ROOT EXTRACTS BY ULTRASONICATION AND MACERATION TECHNIQUES: PHYTOCHEMICAL SCREENING, ANTIMICROBIAL AND ANTIOXIDANT POTENTIALS

摘要

Medicinal plants have been used for medicinal purposes as antibiotics and anti-inflammatory agents in times memorial in most parts of Southern Africa. The study focused on the phytochemical screening, in-vitro examination of antioxidant and antimicrobial potentials of Teedia lucida root extracts in different solvents like methanol, acetone, water, and dichloromethane. The phytochemical investigation of the solvent extracts as a result of two extraction methods: ultrasonication and maceration, revealed the presence of secondary metabolites in the extracts. The total phenols and flavonoids contents varied from 270.801–932.582 GAE mg/g and 160–345.56 QE mg/g in the extract powders respectively. Radical Scavenging Activity (RSA) of the solvent extracts against DPPH radical and quercetin as positive control revealed that dichloromethane extracts by ultrasonication method exhibited 10.28– 66.36 % DPPH scavenging potentials. The antimicrobial activity of methanolic extract possesses MIC values (0.3195 and 0.639 μg/ml), acetone (0.3968 and 0.792 μg/ml) by ultrasonication method against S. aureus and S. sonnei strains respectively. In conclusion, the study demonstrates that different solvent root extracts of T. Lucida contain constituents with antioxidant and antibacterial potentials.