CM013 Quality control – Qualitative testing of enrofloxacin

摘要

Enrofloxacin is a second generation fluoroquinolone, developed in the 80’s with the chemical name acid 1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid and was the first fluoroquinolone introduced to veterinary medicine for the treatment of infections by various bacteria. The molecular formula of enrofloxacin is C19H22FN3O3 as CAS Register Number 93106-60-6 and molecular weight of 359.39 g/mol. Enrofloxacin is a slightly yellow crystal, entering the melting range 219-221 °C and is slowly soluble in water at pH 7.0, but since the molecule has acidic and basic groups it is easily dissolved in alkaline and acidic pH. In the literature there is little information on the characteristics of enrofloxacin. Therefore, a qualitative analysis is very important before doing any quantitative analysis, for it is better possible to understand the nature of the drug studied by analyzing it qualitatively.