Effect of sidr honey on healing of contaminated wounds in alloxan-induced diabetes mellitus in dogs

摘要

The objective of the study was to compare Sidr honey and iodine on healing of co ntaminated wounds in induced diabet es in dogs. Diabetes mellitus was induced in dogs (n=4) using intravenous injection of 120 mg/kg alloxan monohydrate. Status of the diabetes was verified usi ng oral glucose tolerance test. Four (1.5 cm x 1.5 cm) wo unds we re created on each of the research subject's back. Wounds were covered with 2 gm of dog feces under a bandage for 24 hours prior to starting the treatments. In each of the diabetic dogs or control dogs (n=4), 2 wounds (n=8) were treated wit h 1 - 2 ml of 10% povidine iodine and 2 wounds (n=8) were treated with 1 - 2ml of pure Sidr honey. Treatments started twice daily for the first week and then o nce daily for the rest of the stud y. Wounds were left to he al by second intention healing. Healthy control dogs were treated in a similar fashion. Wounds in the alloxan - induced diabetic dogs healed at a slo wer rate. In both groups, honey or iodine treated wounds appeared to heal at a comparable rate. Sidr honey can be considered as a safe natural remedy to manage contami nated wounds.