Effects of Epigallocatechin 3- Gallate in Rat Cardiac Tissue on Oxidant and Antioxidant System Exposed to Sevoflurane Anesthesia

摘要

Summary Objectives: To investigate the possible effects of sevoflurane anesthesia and epigallocatechin 3- gallate (EGCg) on cardiac tissue by evaluating theoxidant and antioxidant status in rats.Materials and Methods: Tree groups of animals were studied. Sevoflurane 3% (v/v) in air/O2 were administered to animals in group 1 (n = 6) andsevoflurane plus EGCg was administered in group 2 (n = 6). Six animals were allocated to control group (group 3). Malondialdehyde (MDA), nitricoxide (NOx), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) in cardiac tissue were studied.Results: In group I, MDA, SOD and GSH-Px levels were significantly increased (p<0.05, p<0.0001, p<0.001, respectively) while non-significantchanges occurred in CAT and NOx activities. Supplementation of EGCg (group 2) decreased the MDA, SOD and GSH-Px activities whereas, theNOx activities increase with EGCg supplementation.Conclusion: The amount of lipid peroxidation and antioxidant enzyme levels were more increased in following sevoflurane administration. Theadministration of intravenous EGCg significantly protected cardiac tissue. ?2007, Firat University, Medical Faculty Top