Comparison of Different Quantitative Methods and Visual Evaluation on the Tc-99m-HMPAO Brain Perfusion SPET

摘要

Summary Objectives: Brain perfusion SPECT has been widely used for evaluation of brain perfusion and metabolic status. We aimed to compare different quantitative methods on Tc-99m-HMPAO SPET based on visual evaluation.Materials and Methods: Forty-seven patients were enrolled in this comparative study. Tc-99m-HMPAO brain SPET was performed. For semiquantitative analysis, two orbitomeatal (OM) composite slices were obtained. Regional cerebral perfusion data were semi-quantitatively computed by the ratio between each cerebral ROI mean-counts and the reference region mean-counts. Mean counts of the cerebellum, mean-counts of lower OM slice and contralateral ROI mean-counts were used as reference regions. Two different nuclear physicians evaluated all images. It was considered 0 (=hypoperfusion area); 1 (=normal perfusion area) and 2 (=hyperperfusion area) by visual evaluation. SPET slice?s region of interest (ROI) data were analyzed by receiver operator characteristics (ROC) method to establish the optimal decision threshold for different quantitative methods.Results: Our results observed that usage of small ROIs were better than larger ones. The mean-counts of lower OM slice had a positive correlation with the cerebellum mean-count. Additionally, as reference regions, mean-counts of lower OM slice was slightly better than cerebellum and evidently better than symmetric region of the contralateral hemisphere.Conclusion: We did not found the expected high correlation among visual analysis and these quantitative methods. We believe that new quantitative methods on the Tc-99m-HMPAO brain perfusion SPET are required. ?2006, Fırat üniversitesi, Tıp Fakültesi Top