Prokineticin-2 is associated with metabolic syndrome in a middle-aged and elderly Chinese population

摘要

Background Prokineticin-2 is confirmed to be involved in the inflammatory process. Inflammation plays an important role in the pathogenesis of metabolic syndrome (MS). However, whether prokineticin-2 is associated with MS or not remains unknown. Thus, we present this study to explore the association between prokineticin-2 and MS in a Chinese population. Methods This study included 162 middle-aged and elderly Chinese patients with cardiovascular risk factors. The relationship between serum prokineticin-2 levels and various cardiometabolic risk factors, and MS were evaluated. Results The participants with serum prokineticin-2 levels >6.32?ng/ml had increased waist circumference, body mass index (BMI), plasma triglyceride, diastolic blood pressure (DBP), blood glucose, and serum uric acid, but decreased age, plasma high-density lipoprotein cholesterol (HDL-C), and HDL-C/total cholesterol (TC) (all P Conclusions Prokineticin-2 is correlated with various cardiometabolic risk factors including blood lipid, blood glucose, blood pressure, BMI, and uric acid. And furthermore, the increased prokineticin-2 is independently associated with MS.