Chronic lymphocytic lymphoma and concomitant renal cell carcinoma (Clear Cell Type): Review of the literature

摘要

In the present report, a 73 years-old male patient who developed clear cell type renal cell carcinoma (RCC) 5 years after the diagnosis of chronic lymphocytic lymphoma (CLL) and plausible explanations for this association were discussed by the authors. The incidence of CLL and RCC occurring in the same patient is higher than that expected in the general population. Various explicative hypotheses of this concurrence include treatment-related development of a second malignancy, immunomodulatory mechanisms, viral aetiology, cytokine (interleukin 6) release from a tumor, and common genetic mutations. Further investigations are warranted. Highlights ? There appears to be an association between lymphoid malignancies and RCC. ? The exact mechanism of this association has not been clarified yet. ? Unexpectedly deep anemia in a CLL patient may be caused by an occult RCC. ? Erythropoietin levels may be helpful in such patients. ? Close monitorization of CLL patients is required in terms of second malignancies.