An intensive approach to treatment for older patients with relapsed isolated NPM1 mutated AML

摘要

We present a short case series of elderly patients with NK-AML and isolated NPM1 mutation who were treated with intensive chemotherapy, achieving significant CRs multiple times on reinduction, even with a single course.We hope to highlight the NPM1 as a molecular marker in elderly for consideration of aggressive treatment, even if abridged, as this subset may achieve a durable, good quality responses at diagnosis or subsequent relapses. Highlights ? Three case reports of elderly AML with NPM1 mutation treated with intensive chemotherapy. ? Multiple relapses managed with reinduction with intensive regimens with good clinical response, even with a single course. ? NPM1 mutation may be used as a molecular marker in elderly patients for consideration of aggressive treatment.