Evaluation of a 12-week lifestyle education intervention with or without partial meal replacement in Thai adults with obesity and metabolic syndrome: a randomised trial

摘要

Background/Objectives There have been no studies examining the efficacy of meal replacement (MR) on weight loss and metabolic syndrome (MS) improvement in Southeast Asians. Thus, we undertook a 12-week randomised trial to evaluate the effect of a lifestyle education intervention alone (LEI) or with partial MR (LEI?+?MR) in obese Thai adults with MS. Subjects/Methods A total of 110 patients were randomised to receive either LEI or LEI?+?MR. Both groups received LEI to achieve weight loss. LEI?+?MR group additionally received two MR daily to replace either breakfast, lunch or dinner. Mean?±?SE body mass index of all participants was 34.6?±?0.6?kg/m~(2), mean?±?SE age was 42.5?±?1.1 years and 83% of patients were female. Both groups were compared for anthropometric and cardiometabolic indices at 12-week. Body weight was also compared at weeks 38 and 64. Results At 12 weeks, both groups exhibited statistically significant percentage weight loss (%WL) compared to initial weight but greater %WL was observed in LEI?+?MR compared to LEI, 2.9% vs. 1.5%, respectively ( p ?