A Study on Malondialdehyde as an Oxidative Stress Marker in Patients with Myocardial Infarction at a Tertiary Care Centre

摘要

Introduction: Acute Myocardial Infarction (AMI) is the most critical event in cardiovascular disorders and arises as a consequence of myocardial ischemia due to coronary occlusion. Oxygen free radicals have become attractive candidates to explain injuries in the heart with growing appreciation that free radicals such as Malondialdehyde (MDA) which is the end product of lipid peroxidation may accumulate during ischemia at low oxygen tension.Aim: This study was done to note any changes in the MDA levels in the AMI in comparison with the controlsMaterials and Methods: A prospective study was done at Kakatiya Medical College, Waranagal, India between April 2010 to March 2011. Blood samples of 30 patients diagnosed as AMI (admitted within 12 hours after onset of ischemic pain) were collected and subjected to serum MDA, CKMB, Aspartate Transaminase (AST), Lactate dehydrogenase (LDH).Results: There was significantly increased mean values in serum MDA levels in (p < 0.001) in the study group as compared to controls. MDA levels significantly correlated with, CK-MB, AST and LDH.Conclusion: The MDA values are significantly increased in AMI indicating oxidative stress associated with AMI. Hence, another potential area of treatment to reduce extent of damage. At their best cut off values CK-MB and MDA had high sensitivity and specificity and good discriminatory capacity in identifying AMI. Though, AST and LDH exhibited good sensitivity, they lack specificity to act as good markers.