Protective effect of Syzygium cuminii (Linn.) Skeels seed extract on lipid peroxidation in alloxan induced diabetic rats

摘要

The effect of Black plum, Syzygium cuminii (Linn.) Skeels (syn. S. jambolanum DC.) seed extract on lipid peroxidation in alloxan induced diabetic rats was studied. Alloxan 150mg (mg/kg body weight) increased significantly the glucose level in blood and induced the Lipid Peroxidation (LPO) in liver. The antioxidant enzymes Catalase (CAT), Reduced Glutathione (GSH), Glutathione peroxidase (GPx), Superoxide dismutase (SOD) in liver were decreased. Oral administration of the extract for 15 days to alloxan treated animals showed remarkable increase in the level of antioxidant enzymes and reduced the level of lipid peroxidation activity and blood glucose. The results suggest that seed extract of the plant is an antioxidant and acute hyperglycaemic drug and might be used in the regulation of lipid peroxidation without detectable adverse side effects.