Aqueous-mediated green synthesis of 3-carboxyxoumarins using grinding technique

摘要

A simple, efficient and green procedure for the synthesis of 3-carboxycoumarins has been developed which involves the grinding of 2-hydroxybenzaldehydes with Meldrum's acid (2,2-dimethyl-1,3-dioxan-4,6-dione) in aqueous moist conditions at room temperature. The protocol is much more efficient as the reactions are carried out at room temperature and yields are also quite high. All the compounds were characterized by their IR, 1H NMR and mass spectral data and compared with authentic samples.