The effect of disease burden on the speed of aging: an analysis of the Sardinian mortality transition

摘要

Abstract According to the constant senescence hypothesis , senescence cannot be accelerated or decelerated by exogenous factors. Two contrasting theories have been proposed in the literature. According to the inflammaging theory , those individuals who have experienced a higher antigenic load will experience more rapid senescence. Instead, the calorie restriction theory stresses that excessive daily calorie intake can produce an acceleration in senescence.To test these theories, this paper analyzes the evolution of the rate of aging in Sardinia (Italy). In this population, the epidemiological transition started without any substantial modification in nutritional levels. This allows us to test the constant senescence hypothesis against the inflammaging theory, without the possible confounding effect produced by the nutrition transition.To accomplish this aim, the longitudinal life tables from 80?years onwards for Sardinian cohorts born between 1866 and 1908 were reconstituted. They were then used to estimate the rate of aging by means of the Gamma-Gompertz model. Coherently with the inflammaging theory, the results show that the Sardinian population experienced a dramatic decrease in the rate of aging that coincided with the onset of the epidemiological transition.