SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW L-LYSINE GLYCOSIDE DERIVATIVES

摘要

Novel glycosides 2-(1,5-diaminopentyl)- S -fructosyl-1,3,4-oxadiazole-5-thione , 3-(1,5-diaminopentyl)-5- S -glucosyl-1,2,4-triazole-5-thiole and 3-(1,5-diaminopentyl)-4-amino-5- S - or 4- N -glucosyl-1,2,4-triazole-5-thiole are obtained by reacting the appropriate azoles with D -fructose and D -glucose. All intermediates and final products are characterized by IR, 1 H-NMR and 13 C-NMR. The antimicrobial activities are assessed using the paper disk diffusion and broth dilution methods against Acinetobacter , Pseudomonas aeruginosa , Bacillus cereus, Staphylococcus aureus and Spongospora subterranean . Some of the synthesized compounds showed promising activity against microorganisms under test in comparison with commercially available antibiotics Polymixine and Oxytetracycline.