Clinical Evaluation on Treatment of Oral Lichen Planus with Yiqiyangyin Mixture and Its Mechanism

摘要

To observe the clinical effects of Chinese herbal medicine Yiqiyangyin Mixture on oral lichen planus (OLP) and to explore its mechanism, we randomly selected two groups of newly diagnosed patients, they were treated with Yiqiyangyin Mixture and total glucosides of paeony(TGP), respectively, for three months, and the clinical effects of the two treatment system were compared by using semi-quantitative REU scoring system; and the changes of NF-κB-dependent inflammatory medium TNF-α, IL-1β, IL-6, IL-8 and TH1/TH2 representative cytokines IFN-γ, IL-10 levels were also observed before and after treatment. The overall effective rates on OLP were no significant difference between trial group and control group, but the therapeutic effect of Yiqiyangyin Mixture on the erosive OLP was more significant, its subjective symptoms and objective signs were all evidently improved, and compared with the TGP group, P <0.05; the changes of NF-κB-dependent inflammatory mediators TNF-α, IL-8 and TH1/TH2 representative cytokine IL-10 were significantly before and after treatment (P < 0.05). It shows that Chinese herbal medicine Yiqiyangyin Mixture is effective for treatment of OLP, especially the effect on erosive OLP is more significant, and the prescription may plays a role through regulating Th1/Th2 immune balance and blocking activation of NF-κB information pathway.