Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats

摘要

Recent studies have shown remote effects of renal Ischemia/Reperfusion (I/R) injury on the liver. Furthermore, I/R injury is correlated with the generation of Reactive Oxygen Species (ROS). This study investigated the effect of Rosa canina on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion at an early stage. There were three groups (n = 10), in which rats received orally 7 days before induction of ischemia, extract of Rosa canina (500 mg kg-1) in RC+I/R group and distilled water in I/R group. In sham group, the renal arteries were not occluded and distilled water was administered orally 7 days before surgery. Renal ischemia was induced by both renal arteries occlusion for 45 min followed by 24 h of reperfusion. Blood samples were collected for bio chemical analysis and finally liver samples were preserved for future histological examination. The renal ischaemic challenge resulted in major histological damages of the liver (0.001), which were associated with increased levels of creatinine, Blood Urea Nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) during reperfusion period (all 0.001). In RC+I/R group, the histological damage to the liver was improved (0.001) along with increased in plasma creatinine, BUN, ALT and AST being smaller than those of the non-treated rats (0.001). Rosa canina exhibited a hepatoameliorative effect against renal ischemia/reperfusion-induced lesions.