Ewing's Sarcoma / PNET: A Histopathological Review

摘要

Ewing's sarcomas (EWS) / Peripheral primitive neuroectodermal tumours (PNET) are small round cell tumours occurring in bone and soft tissues, characterized as a group by the presence of the typical translocation t (11; 22) (q24; q12) and its variants. Diagnosis requires histopathological examination, immunohistochemistry and cytogenetics. There is a spectrum of histological appearance, which reflects the degree of neuroectodermal differentiation in these tumours posing diagnostic difficulties. The current concepts in diagnosing these tumours and the clinical impact of neural differentiation are discussed.