EVALUATION OF BUCHANANIA COCHINCHINESIS GUM AS A BINDER IN FORMULATION DEVELOPMENT OF PARACETAMOL TABLETS

摘要

Objective: An attempt was made to investigate the binding efficacy of Chirauli nut tree gum in tablet formulation in comparison with standard binders such as acacia and polyvinyl pyrrolidone (PVP K-30). Methods: The paracetamol granules were prepared with different concentration of the gum as a binder by wet granulation method. The granules were evaluated and found to be satisfactory for preparing compressed tablets. The tablets were prepared by compression machine and evaluated for volume of tablet, apparent density, porosity, packing fraction, percentage elastic recovery, tablet physical stability, content uniformity, weight variation, hardness, friability, disintegration time, in vitro dissolution studies. Effect of diluents (Microcrystalline cellulose pH 101, Di-calcium Phosphate) and disintegrants (Croscaremellose sodium, Sodium Starch Glycolate and Crospovidone) were also studied using optimized concentration of gum. Results Formulations containing the minimum concentration of 2.5% of gum as a binder showed good physico-mechanical properties and dissolution profile. Conclusions: formulation development of paracetamol tablets using diluents and disintegrants like lactose (Pharmatose 200M), dicalc ium phosphate and sodium starch glycolate, croscarmellose sodium can be used respectively, using 2.5% optimized concentration of chirauli nut tree