FORMULATION, EVALUATION AND COMPARISION OF DISSOLUTION PROFILES OF ESLICARBAZEPINE ACETATE IMMEDIATE RELEASE TABLETS USING NATURAL BINDERS AGAINST SYNTHETIC BINDER

摘要

Objective: The objective of the present study was to formulate, evaluate and compare the dissolution profiles of Eslicarbazepine acetate (ESL) immediate release tablets using natural binders like tapioca starch, maize starch and galbanum, against the synthetic binder like Polyvinyl Pyrrolidone (PVP). Methods: These natural binders were used as novel excipients which formed weak attractive bonds with the drug by complexation during wet granulation and increased the solubility of ESL. Each of these natural and synthetic binders was used separately in different concentrations to prepare immediate release tablets of ESL. Dissolution profiles of these tablets were compared. Results: The in-vitro drug release of F4 (with galbanum 1%) was highest 98.78%, whereas the least drug release of 61.66% was shown by F12 (with PVP 3%). Conclusion: It was seen that the tablets with natural binders showed better release characteristics in comparison to the tablets with synthetic binder PVP. Formulation with galbanum 1% showed best release profile. Galbanum also has antiepileptic property which can act synergistically with Eslicarbazepine acetate to treat seizures. It was also seen that among the various concentrations of binders used formulations with 1% binder showed better release characteristics when compared to 2% and 3%