A Preliminary Study of Hudu?s Score as a Prognostic Scoring System ofPredicting the Risk of Liver Cirrhosis in Patients withChronic Hepatitis B Infection

摘要

Hepatitis B infection long term prognosis is good in the absence of liver cirrhosis. However, therisk of liver cirrhosis developing in chronic Hepatitis B surface antigen positive varies from 1-5/100patients per year. This study aimed at developing a novel prognostic scoring system to predict liver cirrhosisin chronic Hepatitis B patients. A total of 82 chronic Hepatitis B patients were recruited retrospectively in acohort study and their liver Biochemistry, Hepatitis B viral DNA level, viral serology, quantitative HepatitisB e Antigen (qHBeAg) and development of liver cirrhosis were assessed. The data were included in amultivariate logistic regression analysis based on which this prognostic scoring system was established. Asimple scoring system composed of virological and biochemical laboratory parameter was developed to predictliver cirrhosis in chronic Hepatitis B patients. This prognostic score is accurate and reproducible. Theprognostic score ranges between 5 and 15. Patients prognostic score of 5 indicates low risk, 10 high risk and15 very high risk of developing cirrhosis. In conclusion, this study has showed a promising scoring system thatcan be use in predicting the risk of developing liver cirrhosis in chronic Hepatitis B patients.