Clinical Health Care for Long Distance using Matrix Factorization and Mahalanobis Based Sparse Representation Measures for Epilepsy Classification from EEG Signals”

摘要

Using of bone marrow stem cells (BMSCs) for transplantation to treat the damage in liver induced by either chemical compounds or by viruses is considered as in medical application. The availability, easy culture and surviving for a long time are optimistic advantages of using BMSCs in healing the degenerative of hepatic cells. Therefore, the aim of the present study was planned to use BMSCs in combination with selenium (Se) to treat the hepatic damage induced by carbon tetrachloride (CCL4) in male rats. To perform the aim of this study eighty adult albino male rats were divided in nine groups as follows: Group 1: animals were treated with solvent vehicle. Group 2: animals were injected with CCL4 twice weekly for 2 months. Groups 3 and 4: animals were treated with different doses of Se. Groups 5 and 6: animals were injected with CCL4 and low or high dose of Se, respectively. Group 7: animals were injected with CCL4 and single dose of Bone Marrow Derived Mesenchymal Stem Cells (BM-MSCs). Group 8: animals were injected with CCL4 and single dose of Bone Marrow Derived Mesenchymal Stem Cells (BM-MSCs) plus low dose of Se. Group 9: animals were injected with CCL4 and BM-MSCs plus high dose of Se. The results of this study revealed that treatment of male rats with CCL4 increased the levels of the following parameters including rate of the apoptosis, changes in the gene expression of three antioxidants related genes, DNA fragmentation as well as decreased the activity of the gutathione peroxidase (GPx) enzyme. However, treatment of CCL4-treated rats with BM-MSCs combined with low and high dose of Se decreased the apoptosis rates, alterations in the expression of antioxidant related genes, decreased the damage in the DNA induced by CCL4 as well as increased the activity of the antioxidant enzyme GPx in male rats. Therefore, our results suggest that BMSCs could be used in combination with Se in healing the liver damage induced by CCL4 treatment.