DEVELOPMENT AND EVALUATION OF A DIRECTLY COMPRESSIBLE CO-PROCESSED MULTIFUNCTION SUSTAINED RELEASE AGENT FOR ISOSORBIDE MONONITRATE SUSTAINED RELEASE TABLETS

摘要

Directly compressible co-processed sustained release multifunction agent [DCCSRA] comprising povidone and glyceryl behenate in the ratio of 1:1, 1:2 and 1:3 were prepared and evaluated for formulation of sustained release tablets of isosorbide mononitrate. The DCCSRA exhibited good flow and compressibility. The DCCSRA, prepared by hot melting method and co-precipitation method served as a retardant, binder and lubricant in isosorbide mononitrate sustained release tablets. The DCCSRA may be used for manufacturing of isosorbide mononitrate sustained release tablets.