CHEWING GUM: A FRIENDLY ORAL MUCOSAL DRUG DELIVERY SYSTEMby Anand S. Surana, India. 013 REMEDIAL APPROACH: SWINE FLUby Pankaj Pradhan, Neha Kaushik, Pankaj Bhateja, Abhimanyu, India. 014 EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF GLYCOSMIS PENTAPHYLLA ROOTS AGAINST CCl4 – INDUCED ACUTE LIVER INJURY IN RATSby N. Jaya raju*, B. Ganga rao, India. 015 FAST DISSOLVING TABLETS: PREPARATION, CHARACTERIZATION AND EVALUATION: AN OVERVIEW

摘要

A series of new 3-formyl coumarine (2) was synthesized in good yields by replacement of chlorine atom by 2nd amines. In addition, 5-chromeno-pyrido[2,3-d]pyrimidine-4-yl derivatives (5,6) was synthesized by cyclocondensation of 6- aminouracil, the respective ketones and 3-formyl coumarine (2) in one pot-synthesis. Also 2-S-nucleosides analogous of pyrido[2,3-d]-pyrimidines (12-15) was synthesized by a simple method in good yields, The new compounds were evaluated for their anti-inflammatory and analgesic activity. It has been found that the derivatives 5a, 5b, 14a, 14b, 15a and 15c exhibited the dual pharmacological activities with superior gastrointestinal safety profile when compared to indomethacin except 5a which resulted in ulcer lesions in many of the experimental rats.