Research Progress on Corneal Collagen Cross-Linking for Corneal Ulcerative Keratitis

摘要

Corneal collagen cross-linking (CXL) is a photochem therapy for keratoconus, keratectasias and infectious keratitis. Corneal collagen fiber infiltrated with riboflavin, a photosensitizer which generates reactive oxygen species when activated by UVA, was induced to form the cross-links in corneal stroma. The purpose of this paper is to review the basic principle, therapeutic potential of corneal ulcerative disease, existing evidences from laboratory and clinical studies, and relevant limitations, then put forward the advantages of CXL in the treatment of corneal ulcerative disease, and thus provide more possibilities for the treatment of the disease.