Statins are cholesterol-lowering drugs with multiple activities including anti-cancer effects. The objectives of this study were to examine the effects of simvastatin on gastric cancer cells in vivo. The mice models for gastric cancer cells SGC7901 were divided into two groups, control and experimental group. Simvastatin was administered orally to the experimental group, while saline given to the control group. We measured the volume and weight of tumors, and calculated RTV (relative tumor volume), T/C (relative added value of tumor) and the inhibition rate. The data was compared using t test (p< 0.05 was considered as statistically siginificant). Then the expression levels of PCNA, VEGF and Survivin in gastric cancer tissues were examined immunohistochemically. Our results showed that the volumes of tumors of the mice in control and experimental group were 1.943±0.500cm3, 1.227±0.623 cm3 respectively (p< 0.05), while RTV was 28.833±5.988 cm3, 18.842±7.401 cm3 respectively (p< 0.01). T/C, an indication of anti-tumor, was 65.35%. The weights of tumors of the mice in control and experimental group were 1.820±0.550 g, 1.320±0.500 g respectively (p< 0.05). The inhibition rate was 27.47%. The weight of mice in two groups had no significant differences. The PCNA index in the simvastatin group was 41.32±8.24%, while in the control group was 89.25±7.69%. The PCNA, VEGF and Survivin index of simvastatin group was much lower (p< 0.01). We concluded that simvastatin inhibited the growth of gastric cancer cells.
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