Fungicidal Activity and Biological Characteristics of a Novel Natural Product Fungicide: Phenazine-1-carboxamide-derived 18-1

摘要

A novel phenazine-1-carboxamide-derived 18-1 (PCND 18-1) was evaluated in terms of its potential for the development and enrichment of new biofungicides for the control of rice sheath blight caused by Rhizoctonia solani. PCND 18-1 exhibited fungicidal activity against R. solani, showing an inhibition rate of 87.64%, with a 50% effective concentration (EC 50 ) 4.25 μg/mL, regression equation of Y = 0.7105x + 3.8428; and correlation coefficient of 0.9817, which are indicative of its potential as a natural biofungicide. PCND 18-1 also attenuated the pathogenicity of R. solani, which was concentration dependent. Additionally, the action mode of PCND 18-1 against rice sheath blight (R. solani) was protective better than curative activity under greenhouse condition, as reflected by the corresponding EC 50 values of 2.49 and 5.72 μg/mL. PCND 18-1 can translocate in rice with a low translocation capacity and exhibited a higher capacity for upward (root-leaf) translocation than for downward (leaf-root) translocation. Furthermore, PCND 18-1 demonstrated adhesion to leaves but poor tolerance against rain washing. The optimal persistence period of PCND 18-1 on rice was 7 d.