A Novel Electrochemical Sensor for Paracetamol Based on β-Cyclodextrin/Nafion?/Polymer Nanocomposite

摘要

A sensitive electrochemical sensor based on β-cyclodextrin/Nafion?/poly(3,4-ethylenedioxythiophene) nanocomposite modified gold electrode Au/PEDOT/NF/CD was fabricated for thedetermination of paracetamol ACOP in presence of interference compounds. Au/PEDOT/NF/CDshowed an excellent electrocatalytic synergism between its components for the electrooxidation ofACOP. Conductive PEDOT polymer film acts as an electron mediator with a rich electron cloud.Furthermore nafion improves the electrical conductivity of the composite as well it works as suitablelayer for the formation of the CD film over it due to its good adhesion at the polymer surface and goodfilm forming ability. By the modification of Au/PEDOT/NF with CD film, enhanced charge transferkinetics and improved oxidation current for ACOP were obtained. A supramolecular host-guestinclusion complex is formed between β-CD and ACOP via electrostatic, inclusion interactions andhydrogen bonds formation. The formation of such complex resulted in selective advantage andenhancement of the charge transfer properties of ACOP. ACOP molecules penetrate into the less polarcavity of β-CD and ACOP:CD inclusion complex was formed which further resulted in significantincrease in oxidation signal of ACOP. Under optimized conditions a linear calibration curve wasobtained for the determination of ACOP in urine within the range 3–300 μmol L-1, with a correlationcoefficient of 0.9958 and detection limit of 36.1nmol L-1. Simultaneous determinations of ACOP andepinephrine (EP), ACOP and norepinephrine (NE), ACOP, DA and AA and ACOP, EP and AA wereachieved at the modified sensor with high resolution and good potential peak separation.