Voltammetric and LC-MS/MS Method for the Determination of Triclosan – A Comparative Study, Validation and Simultaneous Application

摘要

In this paper, two determination methods of polychlorinated diphenylether triclosan (5-chloro-2-(2,4- dichlorophenoxy)phenol), an antibacterial and antifungal agent, are developed, compared and used inconcordance. The first one, differential pulse voltammetry (DPV) on carbon paste electrode (CPE), issimple, fast, portable and inexpensive and therefore suitable for field measurements, large scalemonitoring and screening purposes. The other one, liquid chromatography with MS/MS detection, ismuch more sophisticated, selective, accurate and sensitive (unfortunately much more expensive aswell) and can serve for more reliable determination of triclosan in samples selected as suspiciousduring the screening measurements. Optimum conditions for both the determinations are described andvalidation parameters in matrices of drinking and river water are given.