PVC Membrane Sensor and Wire Coated Electrode for Determination of Flurazepam

摘要

Flurazepam is a benzodiazepine derivative which possesses anxiolytic, anticonvulsant, sedative andskeletal muscle relaxant properties. This research introduces two kinds of PVC membrane sensor (symmetricand asymmetric) for determination of flurazepam (FLZ) in pharmaceutical formulation. For the membranepreparation, flurazepam-tetraphenyl borate ion-pair was employed as a sensing material in the PVC membrane.Several plasticizers were studied in the membrane composition dibutyl phthalate (DBP), acetophenon (AP),nitrobenzene (NB) and nitrophenyloctyl ether (o-NPOE). After a series of experiments, the best electrodeperformance was made of a membrane composed of DBP. The electrodes illustrated a fast, stable and Nernstian-5 -2response over a wide flurazepam concentration range of 110 to 110 M in case of PVC membrane electrode-6 -3and 110 to 110 M in case of wire coated electrode, in the pH range of 4.0.0. Validation of the methodshows suitability of the sensors for use in the analysis of flurazepam hydrochloride in pharmaceuticalformulation.