Comparative evaluation of i-gel? insertion conditions using dexmedetomidine-propofol versus fentanyl-propofol - A randomised double-blind study

摘要

Background and Aims: i-gelsup?/sup insertion necessitates adequate depth of anaesthesia to prevent laryngospasm, gagging or limb movements. We aimed to compare i-gelsup?/sup insertion conditions with propofol induction after pre-treatment with dexmedetomidine or fentanyl. Methods: Eighty ASAI/II patients undergoing general anaesthesia were randomised into Groups D (n = 40) and F (n = 40). Group D received 1 μg/kg dexmedetomidine over 10 minutes followed by 5ml of 0.9%normal saline (NS) over 2 minutes. Group F received 10 ml of 0.9%NS over 10 minutes followed by fentanyl 1 μg/kg over 2 minutes. Thirty seconds after study drugs, propofol 2 mg/kg was given. Ninety seconds after propofol, i-gelsup?/sup was inserted. Overall insertion conditions were assessed by Modified Scheme of Lund and Stovener. Heart-rate (HR) and mean arterial pressure (MAP) were noted at baseline, after study drug, propofol induction and 1,3,5,10 minutes after i-gelsup?/sup insertion. Respiratory rate and apnoea times were recorded. Results: Insertion conditions were comparable between both groups. Moderately relaxed jaw, coughing and movement was observed in more patients of Group F. Incidence of apnoea was significantly higher (P 0.0001) in group F (18/40) than group D (3/40).Mean duration of apnoea in group F (284.5 ± 11.19 sec) was significantly higher than group D (217.17 ± 16.48 sec). Percentage drop in MAP from baseline after propofol was more in group F (10.3%) than group D (5.6%). MAP after induction was significantly lower in group F compared to group D (P = 0.002), but similar after i-gelsup?/sup insertion, 1,3,5 and 10 minutes after insertion. After propofol (P = 0.003) and i-gelsup?/sup insertion (P 0.001), HR was significantly lower with dexmedetomidine. Conclusion: Dexmedetomidine and fentanyl provide comparable conditions for i-gelsup?/sup insertion with propofol.