Antimalarial potential of leaves crude extract of Monotheca buxifolia

摘要

The human’s malarial infection is transmitted mainly by Plasmodium vivax and Plasmodium falciparum where the most usual cause of malarial infection is Plasmodium vivax which is about 80% of all malarial cases and 10% of the deaths. So the present study was focused on the effects of methanolic crude extract of Monotheca buxifolia leaves at the concentration 200 μg/ml against Plasmodium falciparum and Plasmodium vivax present in human blood samples. The blood samples (n=100) were collected from both the genders of various ages from six union councils namely, Uster Zai, Dhoda, Khormato, Jerma, Bilitang and Chickar Kot of district Kohat. Out of 100 patients, 4 patients were infected by Plasmodium falciparum (male=3, female=1) and 96 were infected by Plasmodium vivax (male=70, female=26). Maximum inhibition (80%) in the growth of Plasmodium falciparum was exhibited by methanolic fraction at the age groups of 6-15, 16-30 and 31-50 years male and female malarial patients. While, in the case of Plasmodium vivax, maximum percentage inhibition was exhibited by methanolic fraction (male=80%, female=82%) at the age group of 31-50 years. The Resochine (40 μg/ml) was used as positive control exhibited 100% inhibition of malarial parasites. Moreover, distilled water was used as negative control (200μl/ml) caused no effect.