A comparative antimicrobial study on Cordia macleodii. hook leaf water extract and its ghrita base formulation

摘要

Cordia macleodii Hook. of family Boraginaceae (Ehretiaceae) is reported for its ethnomedicinal use as a wound healing drug. An attempt has been made to evaluate the antibacterial activity of its leave along with its ghrita base preparation against medically important human pathogenic bacteria (two gram positive- S. aureus, S. pyogenes, two gram negative- E. coli, P. aeruginosa) and fungal strains- A.niger, C. albicans, at different concentrations(5, 25, 50, 100, 250 μg/ml), using agar disc diffusion method. Zone of inhibition of these samples was compared with that of different standards (Ampicilline, Ciprofloxacin, Norfloxacin and Chloramphenicol for antibacterial activity and Nystain and Greseofulvin for antifungal activity). Only ghrita showed more effective result, at different concentration, in comparison to leave water extract and ghrita base formulation