EFFECT OF BENZOIN RESIN ON THE SERUM BILIRUBIN LEVELS IN TEMPORARY JAUNDICE INDUCED BY PHENYLHYDRAZINE: A PRELIMINARY STUDYA

摘要

Bilirubin is the degradation product of heme, the bulk of which is derived from hemoglobin of senescent erythrocytes and hepatic hemoproteins. Bilirubin is potentially toxic, but is normally rendered harmless by binding to plasma albumin, and efficient hepatic clearance. Jaundice, (also known as icterus) is a yellowish pigmentation of the skin, the conjunctival membranes over the sclerae (whites of the eyes), and other mucous membranes caused by hyperbilirubinemia (increased levels of bilirubin in the blood). Complications of jaundice include sepsis especially cholangitis, biliary cirrhosis, pancreatitis, coagulopathy, renal and liver failure. Treatment of rats with Phenylhydrazine 5 mg/ kg body weight for five days resulted in the development of jaundice as BR level was found to be higher than 2 mg/dL. Bilirubin lowering potential of Benzoin ethyl alcohol