IL12?–?Study on the targets and mechanisms of traditional Chinese medicine in inhibiting platelet aggregation

摘要

Platelets aggregation and thrombosis formation are majorreasons of cardiovascular and cerebral vascular diseases.To develop novel, effective and safe agents for inhibitingplatelet aggregation and preventing above diseases isurgently needed. Some traditional Chinese medicinesfor “Houxue Huayu” have been shown to inhibit plateletaggregation potently. They are used frequently in Chinaand also in Asian countries. Recently, the major effectivecomponents of Pueraria lobata, Salvia miltiorrhiza Bunge,Apium graveolens L. and so on were studied. The mechanismsand the molecular targets of puerarin, salvianolic acid B andthe analogue of 3-n-butylphthalide, dl-PHPB were investigated.Four platelet aggregation inducers, ADP, arachidonicacid (AA), collagen (Col) and thrombin, were used in thestudy.